812-GA1Nt 812-GA1N
Promo Available
Anti-GABAA Receptor α1, N-Terminus Antibody
PhosphoSolutions
DESCRIPTION
Our Anti-GABAA Receptor α1, N-Terminus primary antibody from PhosphoSolutions is rabbit polyclonal. It detects mouse and rat GABAA Receptor α1, N-Terminus and is antigen affinity purified. It is great for use in WB, IHC.
DETAILS
- Form: Antigen Affinity Purified
- Gene: GABRA1
- Host: Rabbit
- Rrid: AB_2492100
- Type: Primary Antibody
- Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
- Target: GABAA Receptor α1, N-Terminus
- Isotype: IgG
- Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
- Shipping: Blue Ice
- Synonyms: ECA4 antibody, EIEE19 antibody, EJM antibody, EJM5 antibody, Gaba receptor alpha 1 polypeptide antibody, GABA(A) receptor antibody, GABA(A) receptor subunit alpha 1 antibody, GABA(A) receptor subunit alpha-1 antibody, GABA(A) receptor, alpha 1 antibody, GABRA 1 antibody, GABRα1 antibody, Gamma aminobutyric acid (GABA) A receptor alpha 1 antibody, Gamma aminobutyric acid A receptor alpha 1 antibody, Gamma aminobutyric acid type A receptor alphα1 subunit antibody
- Clonality: Polyclonal
- Immunogen: Synthetic peptide corresponding to amino acid residues from the N-terminal region of the α1 subunit of rat GABAA, conjugated to keyhole limpet hemocyanin (KLH).
- Expiration: After date of receipt, stable for at least 1 year at -20°C.
- Specificity: Specific for endogenous levels of the ~51 kDa α1-subunit of the GABAA receptor. Immunolabeling is absent in α1-subunit knockout animals.
- Applications: WB, IHC
- Ncbi Gene Id: 29705
- Conjugate Exem: Unconjugated
- Physical State: Liquid
- Quality Control: Western blots performed on each lot.
- Usage Statement: For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
- Molecular Weight: 51
- Production Notes: Prepared from pooled rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.
- Dilution Range Wb: 1:1000
- Immunogen Species: Rat
- Dilution Range Ihc: 1:100
- Species Reactivity: Mouse and Rat
- Target Description: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABA-A receptor (GABA-A-R) subtype. GABA-A-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABA-A-Rs sensitive to GABA. However, coexpression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003).
- Expected Reactivity: Bovine, Canine, Human, Non-Human Primate
- Dilution Range Wb Brain: 1:1000
- Uniprot Number Immunogen Species: P62813
PROMOTION TERMS
Trial Size Available. Limit 1
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