Monoclonal Antibody to TRF2 (Clone: ABM10H3)

DESCRIPTION

TRF2 (Telomere Repeat Binding Factor 2), a subunit of the shelterin complex, binds to duplex telomeric DNA and plays a crucial role in telomere protection. TRF2 contains an N-terminal basic domain rich in glycines and arginines (the GAR domain), a central TRFH dimerization domain, a flexible linker region and a C-terminal Myb-like DNA binding domain. TRF2 undergoes extensive post-translational modification, which in turn regulates its stability, DNA binding and cellular localization. Ubiquitylation of TRF2 by Siah1, an E3 ligase, promotes TRF2 degradation and replicative senescence of human primary fibroblasts. TRF2 is phosphorylated in response to DNA damage and this phosphorylation has been implicated in DNA double strand break repair.

DETAILS

Gene: TERF2
App Id: IHC,WB
Antigen: TRF2
Gene Id: 7014
Isotype: Mouse IgG1 Kappa
Format Id: Purified
Clone Name: ABM10H3
Uniprot Id: Q15554
Host Animal: Mouse
Clonality Id: Monoclonal
Purification: Protein G Chromatography
Reactivity Id: Human
Product Content: 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Alternative Name: TERF2||TRBF2||TRF2
Application Note: Western blot analysis: 2-4 µg/ml, Immunohistochemical analysis: 5 µg/ml
Storage Condition: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: Full length recombinant TRF2 protein was used as the immunogen for this antibody.