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PON-V52H3-50ug PON-V52H3-500ug

Nipah virus Post-Fusion glycoprotein, His Tag (MALS verified)

ACROBiosystems

DESCRIPTION

Nipah virus Post-Fusion glycoprotein, His Tag (PON-V52H3) is expressed from human 293 cells (HEK293).

DETAILS

  • Tag: C-10×His
  • Host: HEK293
  • Size: 50ug
  • Buffer: PBS
  • Format: Powder
  • Purity: 90%
  • Storage: -20℃
  • Category: Viral Proteins
  • Molecule: Post-Fusion glycoprotein
  • Conjugate: Unconjugated
  • Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
  • Background: Hendra virus (HeV) and Nipah virus (NiV) are henipaviruses discovered in the mid-to late 1990s that possess a broad host tropism and are known to cause severe and often fatal disease in both humans and animals. HeV and NiV infect host cells through the coordinated efforts of two envelope glycoproteins. The G glycoprotein attaches to cell receptors, triggering the fusion (F) glycoprotein to execute membrane fusion. G is a type II homotetrameric transmembrane protein responsible for binding to ephrinB2 or ephrinB3 (ephrinB2/B3) receptors. F is a homotrimeric type I transmembrane protein that is synthesized as a premature F0 precursor and cleaved by cathepsin L during endocytic recycling to yield the mature, disulfide-linked, F1 and F2 subunits. Upon binding to ephrinB2/B3, NiV G undergoes conformational changes leading to F triggering and insertion of the F hydrophobic fusion peptide into the target membrane. Subsequent refolding into the more stable post-fusion F conformation drives merger of the viral and host membranes to form a pore for genome delivery to the cell cytoplasm.
  • Swiss-prot: Q9IH63
  • Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 54.5 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Endotoxin Level: 1.0 EU per μg
  • Molecular Weight: 54.5 kDa
  • Shipping Condition: RT
  • Species Reactivity: Nipah virus
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