F12 Antibody (N-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 2161
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: F12
Other Names: Coagulation factor XII, Hageman factor, HAF, Coagulation factor XIIa heavy chain, Beta-factor XIIa part 1, Beta-factor XIIa part 2, Coagulation factor XIIa light chain, F12
Availability: 2 weeks
Bio Background: This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI.
Bio References: Houlihan, L.M., et al. Am. J. Hum. Genet. 86(4):626-631(2010) Calafell, F., et al. Hum. Mol. Genet. 19(3):517-525(2010) Katakami, N., et al. Diabetes Care 33(2):390-395(2010) Back, J., et al. Biochem. Biophys. Res. Commun. 391(1):11-17(2010) Joseph, K., et al. Ann. Allergy Asthma Immunol. 104(1):50-54(2010) Bunkenborg, J., et al. Proteomics 4(2):454-465(2004) Hiller, O., et al. J. Biol. Chem. 275(42):33008-33013(2000)
Primary Accession: P00748