10444
Scientist.com Supplier
PCI 34051
Cayman Chemical
DESCRIPTION
A potent HDAC8 inhibitor (IC50 = 0.01 μM) with >200-fold selectivity over HDAC isoforms 1, 2, 3, 6, and 10 (IC50s = 4, >50, >50, 2.9, and 13 μM, respectively); induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias (GI50s = 2.4 - 4 μM)
DETAILS
- Inchi: InChI=1S/C17H16N2O3/c1-22-15-6-2-12(3-7-15)11-19-9-8-13-4-5-14(10-16(13)19)17(20)18-21/h2-10,21H,11H2,1H3,(H,18,20)
- Purity: ≥95%
- Raptas: Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation
- Smiles: ONC(C1=CC2=C(C=CN2CC3=CC=C(OC)C=C3)C=C1)=O
- Inchikey: AJRGHIGYPXNABY-UHFFFAOYSA-N
- Cas Number: 950762-95-5
- Formulation: A crystalline solid
- Storage Temp: -20
- Shipping Temp: -20
- Formula Markup: C17H16N2O3
- Formula Weight: 296.3
- Shelf Life Days: 1460