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10444

Scientist.com Supplier

PCI 34051

Cayman Chemical

- Open Babel Depiction HO N OH CH 3 N O

DESCRIPTION

A potent HDAC8 inhibitor (IC50 = 0.01 μM) with >200-fold selectivity over HDAC isoforms 1, 2, 3, 6, and 10 (IC50s = 4, >50, >50, 2.9, and 13 μM, respectively); induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias (GI50s = 2.4 - 4 μM)

DETAILS

  • Inchi: InChI=1S/C17H16N2O3/c1-22-15-6-2-12(3-7-15)11-19-9-8-13-4-5-14(10-16(13)19)17(20)18-21/h2-10,21H,11H2,1H3,(H,18,20)
  • Purity: ≥95%
  • Raptas: Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation
  • Smiles: ONC(C1=CC2=C(C=CN2CC3=CC=C(OC)C=C3)C=C1)=O
  • Inchikey: AJRGHIGYPXNABY-UHFFFAOYSA-N
  • Cas Number: 950762-95-5
  • Formulation: A crystalline solid
  • Storage Temp: -20
  • Shipping Temp: -20
  • Formula Markup: C17H16N2O3
  • Formula Weight: 296.3
  • Shelf Life Days: 1460