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120-41

Recombinant Human GASP-1

PeproTech

DETAILS

  • Gene Id: 124857
  • Uniprot: Q8TEU8
  • Activity: Determined by its ability to inhibit human Myostatin (GDF-8) activity in MCP-11 cells. The ED50 for this effect is 0.0025-0.0040 ug/ml in the presence of 5ng/ml of human Myostatin (GDF-8).
  • Category: RUO Cytokines
  • Subcategory: Growth Factors & Cytokines
  • Research Areas: Angiogenesis/Cardiovascular, Bone, Skeletal, Cartilage, Cell Culture, Diabetes/Weight Regulation, Stem Cells and Differentiation, TGF-beta Superfamily
  • Alternative Names: GDF-associated serum protein-1, GASP, KIAA0443, WFIKKNRP
  • Species of Origin: Human
  • Expression System Source: CHO cells

DESCRIPTION

Growth and differentiation factor-associated serum protein-1 (GASP-1) is a secreted inhibitory TGF-beta binding protein that contains multiple protease inhibitor structural domains. It is expressed primarily in the ovary, testis, and brain, and can act as a potent soluble inhibitor of myostatin and GDF-11, but not Activin A. The GASP-1 gene encodes a 571 amino acid protein that contains a 29 amino acid secretion signal sequence, and multiple identifiable structural features, including a WAP domain, a follistatin/Kazal domain, an immunoglobulin domain, two tandem Kunitz domains, and a netrin domain. Recombinant Human GASP-1 is a 542 amino acid protein that migrates at an apparent molecular weight of approximately 55-66 kDa by SDS-PAGE analysis under non-reducing conditions. The calculated molecular weight of Recombinant Human GASP-1 is 59.9 kDa.