Rapamycin

DESCRIPTION

Rapamycin was first evaluated as an antifungal agent, but is now studied for its potent immunosuppressive and antiproliferative properties. It forms a complex with FKBP12 and directly binds to mTORC1, inhibiting the functions of the mTOR pathway. Rapamycin is reported to block protein synthesis, arrest cell cycle progression, and inhibit IL-2 signal transduction mechanisms.

DETAILS

Purity: ≥95%
Synonyms: Sirolimus, Rapamune, AY 22989
Cas Number: 53123-88-9
References: Nourse, J., Firpo, E., Flanagan, W. M., Coats, S., Polyak, K., Lee, M. H., ... & Roberts, J. M. (1994). lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin. Kuo, C. J., Chung, J., Fiorentino, D. F., Flanagan, W. M., Blenis, J., & Crabtree, G. R. (1992). Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature, 358(6381), 70-73. Hidalgo, M., & Rowinsky, E. K. (2000). The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene, 19(56), 6680-6686.
Application: FA
Formulation: Crystalline solid
Chemical Name: (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)9,10,12,13,14,21,22,23,24,25,26,27,32,33,34, 34a-hexadecahydro-9,27-dihydroxy-3-[(1R)-2[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4] oxaazacyclohentriacontine1,5,11,28,29 (4H,6H,31H)-pentone
Molecular Weight: 914.2
Molecular Formula: C51H79NO13
Storage Conditions: Product should be kept at -20°C.
Pubchem Openeye Can Smiles: CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC