T68568
Encequidar, HCl
TargetMol
DESCRIPTION
Encequidar, also known as HM-30181, is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. Encequidar showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitaxel in MDCK monolayers (IC(50)=35.4nM). Encequidar is currently under clinical trials.
DETAILS
- Cas: 849675-88-3
- Purity: 98%
- Smiles: Cl.COc1cc2CCN(CCc3ccc(cc3)-n3nnc(n3)-c3cc(OC)c(OC)cc3NC(=O)c3cc(=O)c4ccccc4o3)Cc2cc1OC
- Category: Compound
- Molecular Weight: 725.2
- Molecular Formula: C38H37ClN6O7
Lead Time: 4 - 5 weeks
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