Animal-Free Recombinant Human FGF-21

DESCRIPTION

FGF-21 is a secreted growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-21, in the presence of beta-Klotho as a protein cofactor, signals through FGFR 1c and 4 receptors, and stimulates insulin-independent glucose uptake by adipocytes. Recombinant Human FGF-21 is a 19.5 kDa protein containing 182 amino acid residues.

DETAILS

Gene Id: 26291
Uniprot: Q9NSA1
Activity: Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells. The expected ED50 for this effect is 0.3-0.6 ug/ml, in the presence of murine Klotho.
Category: RUO Cytokines
Subcategory: Animal-Free Cytokines
Research Areas: Angiogenesis/Cardiovascular, Bone, Skeletal, Cartilage, Cancer, FGF Superfamily, Immune System, Inflammation, Neurobiology, Stem Cells and Differentiation, Wound Healing
Alternative Names: Fibroblast Growth Factor-21, FGFL
Species of Origin: Human
Expression System Source: E.coli