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Animal-Free Recombinant Human FGF-21



  • Gene Id: 26291
  • Uniprot: Q9NSA1
  • Activity: Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells. The expected ED50 for this effect is 0.3-0.6 ug/ml, in the presence of murine Klotho.
  • Category: RUO Cytokines
  • Subcategory: Animal-Free Cytokines
  • Research Areas: Angiogenesis/Cardiovascular, Bone, Skeletal, Cartilage, Cancer, FGF Superfamily, Immune System, Inflammation, Neurobiology, Stem Cells and Differentiation, Wound Healing
  • Alternative Names: Fibroblast Growth Factor-21, FGFL
  • Species of Origin: Human
  • Expression System Source: E.coli


FGF-21 is a secreted growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-21, in the presence of beta-Klotho as a protein cofactor, signals through FGFR 1c and 4 receptors, and stimulates insulin-independent glucose uptake by adipocytes. Recombinant Human FGF-21 is a 19.5 kDa protein containing 182 amino acid residues.