Phorbol 12-myristate 13-acetate (PMA)

DESCRIPTION

Phorbol 12-myristate 13-acetate (PMA) is a diester of phorbol and activates the signal transduction enzyme protein kinase C (PKC). It is used as a tumor promoter and to stimulate division of B-cells. With ionomycin, PMA induces the activation of many cell types to produce cytokines.

DETAILS

Purity: ≥98%
Synonyms: PMA, TPA, Phorbol ester, croton oil.
Cas Number: 16561-29-8
References: Emerit, I., & Cerutti, P. A. (1981). Tumour promoter phorbol-12-myristate-13-acetate induces chromosomal damage via indirect action. Holtmann, H. E. L. M. U. T., & Wallach, D. A. V. I. D. (1987). Down regulation of the receptors for tumor necrosis factor by interleukin 1 and 4 beta-phorbol-12-myristate-13-acetate. The Journal of Immunology, 139(4), 1161-1167. Thompson, C. B., Lindsten, T., Ledbetter, J. A., Kunkel, S. L., Young, H. A., Emerson, S. G., ... & June, C. H. (1989). CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proceedings of the National Academy of Sciences, 86(4), 1333-1337.
Application: FA
Formulation: Crystalline solid
Chemical Name: 12-O-Tetradecanoylphorbol-13-acetate
Molecular Weight: 616.8
Molecular Formula: C36H56O8
Storage Conditions: Product should be kept at -20°C.
Pubchem Openeye Can Smiles: CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C