BACE1D Antibody (Center) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 23621
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: BACE1
Other Names: Beta-secretase 1, Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, BACE1, BACE, KIAA1149
Availability: 2 weeks
Bio Background: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the BACE1. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.
Bio References: Christensen, M.A., et al., Mol. Cell. Biol. 24(2):865-874 (2004).Lichtenthaler, S.F., et al., J. Biol. Chem. 278(49):48713-48719 (2003).Hussain, I., et al., J. Biol. Chem. 278(38):36264-36268 (2003).Basi, G., et al., J. Biol. Chem. 278(34):31512-31520 (2003).Clarimon, J., et al., J. Neurol. 250(8):956-961 (2003).
Primary Accession: P56817
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP6104a was selected from the Center region of human BACE1D . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.