Oxaliplatin

DESCRIPTION

A DNA-crosslinking agent; induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein crosslinks, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells; is cytotoxic to cisplatin-sensitive A2780(1A9) and KB-3-1 cells and cisplatin-resistant A2780-E(80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2.7 µM, respectively); reduces tumor growth in an HCCLM3 mouse xenograft model at 5 or 10 mg/kg once per week

DETAILS

Inchi: InChI=1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2
Purity: ≥98%
Raptas: Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|DNA Damage and Repair||Research Area|Cancer|Multidrug Resistance||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis
Smiles: O=C1[O-][Pt+2]2([NH2]C(CCCC3)C3[NH2]2)[O-]C1=O
Inchikey: ZROHGHOFXNOHSO-UHFFFAOYSA-L
Cas Number: 61825-94-3
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C8H14N2O4Pt
Formula Weight: 397.3
Shelf Life Days: 1460