RP00267
Recombinant Human NKG2D ligand 2/ULBP2 Protein
ABclonal
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DESCRIPTION
ULBP2 Protein, Human, Recombinant (His Tag) consists of 203 amino acids with a molecular weight of 23.2 kDa. The apparent molecular mass of recombinant human ULBP2 is about 33 kDa in SDS-PAGE under reducing conditions because of glycosylation.NKG2D ligand 2 is cell membrane protein belonging to theMHC class I family.The gene for ULBP-2 resides in a cluster of ten related genes, six of which encode potentially functional glycoproteins. ULBPs are known to bind to human NKG2D, an activating receptor expressed on NK cells, NKT cells, gamma δ T cells, and CD8+ alpha beta T cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway.ULBP2 / N2DL-2 is not expressed in normal tissues, but in various types of cancer cell lines and the fetus and has been implicated in tumor surveillance.
DETAILS
- Tag: C-hFc&His
- Source: HEK293 cells
- Gene Id: 80328
- Species: Human
- Lead Time: 3-5 weekdays
- Swiss Prot: Q9BZM5
- Research Areas: Other Recombinant Protein
- Alternative Names: ULBP2,ALCAN-alpha,N2DL2,NKG2DL2,RAET1H
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