ALN-H51H5-200ug ALN-H51H5-1mg
Human Alpha-Synuclein (A53T) Protein, His Tag (MALS verified)
ACROBiosystems
DESCRIPTION
Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
DETAILS
- Tag: C-10×His
- Host: E. coli
- Size: 200ug
- Buffer: 100 mM NaAC, pH7.0
- Format: Powder
- Purity: 90%
- Source: Human Alpha-Synuclein (A53T), His Tag (ALN-H51H5) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1 (A53T)).
- Storage: -20℃
- Category: Other Recombinant Proteins
- Molecule: Alpha-synuclein
- Conjugate: Unconjugated
- Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- Exp Region: Met 1 - Ala 140
- Swiss-prot: P37840-1 (A53T)
- Package Size: 200ug*1
- Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.4 kDa. The protein migrates as 18-19 kDa under reducing (R) condition (SDS-PAGE).
- Endotoxin Level: 1.0 EU per μg
- Molecular Weight: 16.4 kDa
- Shipping Condition: RT
- Species Reactivity: Human
- Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html