Polyclonal Antibody to c-Cbl (Ab-700)

DESCRIPTION

Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein igase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.

DETAILS

Gene: CBL
App Id: WB,IHC
Antigen: c-Cbl (Ab-700)
Gene Id: 867
Isotype: Rabbit IgG
Format Id: Purified
Uniprot Id: P22681
Host Animal: Rabbit
Clonality Id: Polyclonal
Reactivity Id: Human
Product Content: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Alternative Name: Signal transduction protein CBL|| Proto-oncogene c-CBL|| Casitas B-lineage ymphoma proto-oncogene|| RING finger protein 55
Application Note: Predicted MW: 120kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Storage Condition: Store the antibody at 4°C, stable for 6 months. For ong-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: Peptide sequence around aa. 698~702 (T-E-Y-M-T) derived from Human c-Cbl.