DESCRIPTION

• Target: Mitofusin 2
• Gene Id: 170731
• Isotype: IgG2a
• Conjugate: APC
• Immunogen: Fusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2. Rat: 97% identity (226/231 amino acids identical). Human: 92% identity (214/231 amino acids identical) ~55% identity with Mitofusin-1.
• Swiss-prot: Q80U63
• Specificity: Detects ~90kDa. No cross-reactivity against Mitofusin-1.
• Applications: WB | IHC | ICC/IF
• Clone Number: N153/5 (Formerly sold as S153-5)
• Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
• Host Species: Mouse
• Product Type: Monoclonal
• Purification: Protein G Purified
• Concentration: 1 mg/ml
• Research Areas: Cell Signaling | Neuroscience | Neurodegeneration | Cell Markers | Cancer | Apoptosis
• Storage Buffer: PBS pH 7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
• Accession Number: NP_573464.2
• Alternative Names: CMT2A Antibody, CMT2A2 Antibody, CPRP 1 Antibody, CPRP1 Antibody, Fzo Antibody, HSG Antibody, hyperplasia suppressor gene Antibody, Hypertension related protein 1 Antibody, KIAA0214 Antibody, MARF Antibody, MFN 2 Antibody, Mfn2 Antibody, Mitochondrial assembly regulatory factor Antibody, Mitofusin-2 Antibody, Mitofusin2 Antibody, Transmembrane GTPase MFN2 Antibody
• Antibody Dilution: WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
• Cite This Product: StressMarq Biosciences Cat# SMC-457D-APC, RRID: AB_2701983
• Immunogen Species: Human
• Storage Temperature: Conjugated antibodies should be stored according to the product label
• Shipping Temperature: Blue Ice or 4ºC
• Cellular Localization: Mitochondrion | Mitochondrion Outer Membrane
• Scientific Background: Mitofusin-2 (Mfn2) is a membrane protein of the mitochondria and is important in mitochondrial fusion in mammalian cells. Mfn2 activity has also been implicated in mitochondrial metabolism and the loss of Mfn2 may be the reason for certain metabolic modifications that are seen in individuals with obesity. Mfn2 has been associated with maintaining the membrane potential of the mitochondria. Mfn2 has been shown to hinder mitochondrial antiviral signaling by inhibiting production of type 1 interferons. Mfn2 is a p53-inducible target and involved in cell proliferation, apoptosis promotion and tumor suppression.
• Certificate of Analysis: 1 µg/ml of SMC-457 was sufficient for detection of Mitofusin-2 in 20 µg of mouse cardiac mitochondrial lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
• Species Reactivity Full Name: Human | Mouse | Rat