1936-SYNJt 1936-SYNJ
Promo Available
Anti-Synaptojanin 1 Antibody
PhosphoSolutions
DESCRIPTION
Our Anti-Synaptojanin 1 primary antibody from PhosphoSolutions is mouse monoclonal. It detects rat Synaptojanin 1 and is Protein G purified. It is great for use in WB, IHC.
DETAILS
- Form: Protein G Purified
- Gene: SYNJ1
- Host: Mouse
- Rrid: AB_2492249
- Type: Primary Antibody
- Clone: 5H1
- Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
- Target: Synaptojanin 1
- Isotype: IgG1
- Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
- Shipping: Blue Ice
- Synonyms: 4 antibody, 5-trisphosphate 5-phosphatase 1 antibody, Inositol 5' phosphatase (synaptojanin 1) antibody, Inositol 5' phosphatase antibody, INPP 5G antibody, INPP5G antibody, KIAA0910 antibody, PARK20 antibody, Polyphosphoinositide phosphatase antibody, Synaptic inositol 1 4 5 trisphosphate 5 phosphatase 1 antibody, Synaptic inositol 145 trisphosphate 5 phosphatase 1 antibody, Synaptic inositol-1 antibody, Synaptojanin antibody, Synaptojanin 1 antibody, Synaptojanin 1 polyphosphoinositide phosphatase antibody, Synaptojanin-1 antibody, Synaptojanin1 antibody, Synj 1 antibody, Synj1 antibody, SYNJ1_HUMAN antibody
- Clonality: Monoclonal
- Immunogen: Recombinant protein from the C-terminal region of rat synaptojanin 1.
- Expiration: After date of receipt, stable for at least 1 year at -20°C.
- Specificity: Specific for endogenous levels of the ~145 kDa synaptojanin I protein in Western blots of rat brain extracts. Immunolabeling blocked by preadsorption of antibody with the protein used to generate the antibody.
- Applications: WB, IHC
- Ncbi Gene Id: 85238
- Conjugate Exem: Unconjugated
- Physical State: Liquid
- Quality Control: Western blots performed on each lot.
- Usage Statement: For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
- Molecular Weight: 145
- Production Notes: Protein G purified culture supernatant.
- Dilution Range Wb: 1:1000
- Immunogen Species: Rat
- Dilution Range Ihc: 1:100
- Species Reactivity: Rat
- Target Description: Synaptojanin is a phosphatidylinositol phosphatase involved in clathrin-mediated endocytosis of synaptic vesicles. Synaptojanin 1 has two alternatively spliced isoforms; one that is ~ 145 kDA and is exclusively expressed in neurons, and the other ~ 170 kDa which is expressed in non-neuronal, peripheral tissues (Ramjaun AR & McPherson PS, 1996). The gene which encodes Synaptojanin 1, SYNJ1, has been mapped to chromosome 21 thus making it a candidate for involvement in Down’s syndrome (DS). It has recently been demonstrated that Ts65Dn mice (the most commonly used model of DS) have altered phosphatidylinositol-4,5- bisphosphate metabolism. This defect is rescued by restoring SYNJ1 to disomy in the Ts65Dn mice (Voronov SV et al., 2008).
- Dilution Range Wb Brain: 1:1000
- Uniprot Number Immunogen Species: Q62910
PROMOTION TERMS
Trial Size Available. Limit 1
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