EC 23

DESCRIPTION

EC 23 is a photostable synthetic analog of all-trans retinoic acid (ATRA). Retinoic Acid is vitamin A derivative that is an agonist for the retinoic acid receptors, which act as transcription factors that regulate the growth and differentiation of normal and malignant cells. It is reported to promote the differentiation of embryonic cells into motor neurons, pancreatic progenitors and cardiomyocytes.

DETAILS

Purity: ≥98%
Synonyms: AGN-190205, EC23
Cas Number: 104561-41-3
References: Clemens, G., Flower, K. R., Henderson, A. P., Whiting, A., Przyborski, S. A., Jimenez-Hernandez, M., ... & Gardner, P. (2013). The action of all-trans-retinoic acid (ATRA) and synthetic retinoid analogues (EC19 and EC23) on human pluripotent stem cells differentiation investigated using single cell infrared microspectroscopy. Molecular BioSystems, 9(4), 677-692. Maltman, D. J., Christie, V. B., Collings, J. C., Barnard, J. H., Fenyk, S., Marder, T. B., ... & Przyborski, S. A. (2009). Proteomic profiling of the stem cell response to retinoic acid and synthetic retinoid analogues: identification of major retinoid-inducible proteins. Molecular Biosystems, 5(5), 458-471. Barnard, J. H., Collings, J. C., Whiting, A., Przyborski, S. A., & Marder, T. B. (2009). Synthetic retinoids: structure–activity relationships. Chemistry–A European Journal, 15(43), 11430-11442.
Application: FA
Formulation: Crystalline solid
Chemical Name: 4-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)ethynyl]benzoic acid
Molecular Weight: 332.4
Molecular Formula: C23H24O2
Storage Conditions: Product should be kept at -20°C.
Pubchem Openeye Can Smiles: CC1(CCC(C2=C1C=CC(=C2)C#CC3=CC=C(C=C3)C(=O)O)(C)C)C