Anti-Caspase-3 (N-terminal region) Antibody

DETAILS

Form: Protein A Purified
Gene: CASP3
Host: Mouse
Rrid: AB_1944428
Type: Primary Antibody
Clone: M377
Buffer: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Target: Caspase-3 (N-terminal region)
Isotype: IgG2a
Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Shipping: Blue Ice
Synonyms: Caspase,-3, CPP-32, Apoptain, Yama, SCA-1, CASP-2, NEDD2, ICH-1, p18, p13, p12
Clonality: Mouse Monoclonal
Immunogen: Clone (M377) was generated from a recombinant protein containing amino acid residues in the N-terminal region of human Caspase-3.
Expiration: After date of receipt, stable for at least 1 year at -20°C.
Specificity: The antibody detects a 32 kDa* protein corresponding to the molecular weight of Caspase-3 on SDS-PAGE immunoblots of human Jurkat and K562 cells.
Applications: WB, ICC
Conjugate Exem: Unconjugated
Physical State: Liquid
Quality Control: Western blots performed on each lot.
Usage Statement: For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
Molecular Weight: 32
Dilution Range Wb: 1:1000
Immunogen Species: Human
Dilution Range Icc: 1:100
Species Reactivity: Human
Target Description: The caspases are a group of cysteine enzymes, which cleave proteins in response to intrinsic and extrinsic pathways that cause apoptotic cell death. The caspases can be grouped into two subgroups based on their roles in apoptosis. Initiator caspases (caspases 2, 8, 9, and 10) are activated through the apoptosis-signaling pathways and activate the effector caspases (caspases 3, 6, and 7) which carry out apoptosis. Caspase cascades are initiated through assembly of multiprotein complexes that trigger activation of the initiator caspases, which are then released and are able to activate the downstream effector caspases.
Uniprot Number Immunogen Species: P42574