ALN-H5117-200ug ALN-H5117-1mg
Human Alpha-Synuclein (E46K) Protein, Tag Free (MALS verified)
ACROBiosystems
DESCRIPTION
Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
DETAILS
- Tag: Native
- Host: E. coli
- Size: 200ug
- Buffer: 50mM HEPES, 100mM NaCl, pH8.0
- Format: Liquid
- Purity: 95%
- Source: Human Alpha-Synuclein (E46K), Tag Free (ALN-H5117) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1 (E46K)).
- Storage: -70℃
- Category: Other Recombinant Proteins
- Molecule: Alpha-synuclein
- Conjugate: Unconjugated
- Stability: ● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 3 months under sterile conditions.
- Exp Region: Met 1 - Ala 140
- Swiss-prot: P37840-1 (E46K)
- Package Size: 200ug*1
- Characteristics: This protein carries no "tag". The protein has a calculated MW of 14.5 kDa. The protein migrates as 16 kDa under reducing (R) condition (SDS-PAGE).
- Endotoxin Level: 1.0 EU per μg
- Molecular Weight: 14.5 kDa
- Shipping Condition: Dry ice
- Species Reactivity: Human
- Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html