mouse monoclonal IgG1; USP15 Antibody (2D5) is an IgG1 κ mouse monoclonal USP15 antibody that detects USP15 of mouse, rat and human origin by WB, IP, IF and ELISA. USP15 Antibody (2D5) is available as the non-conjugated anti-USP15 antibody form. The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP15 (ubiquitin specific peptidase 15), also known as UNPH4, is a member of the peptidase C19 family of proteins. Expressed in kidney, liver, placenta, ovary, lung, thymus, heart and skeletal muscle, USP15 localizes to the cytoplasm and the nucleus, contains one DUSP domain and functions as a deubiquitinating enzyme that cleaves ubiquitin residues from both ubiquitinylated proteins and ubiquitin-fused precursors, thereby saving these proteins from proteasomal degradation. Via its DUSP domain, USP15 plays a role in the regulation of the COP9 signalosome (CSN) complex. Three isoforms exist for USP15 due to alternative splicing events.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.