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310-09B

Recombinant Human LIGHT

PeproTech

DESCRIPTION

LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTbetaR, or bind to a decoy receptor, DcR3. It is expressed in splenocytes, activated PBL, CD8+ tumor infiltrating lymphocytes, granulocytes, and monocytes. LIGHT has the ability to activate NF-kappaB, to co-stimulate the activation of lymphocytes and to induce apoptosis in certain human tumor cells. The human LIGHT gene encodes for a 240 amino acid type II transmembrane protein containing a 37 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 182 amino acid extracellular domain. Recombinant Human LIGHT has a calculated mass of 19.3 kDa, containing 177 amino acid residues. Due to glycosylation, LIGHT migrates between 20.0-22.5 kDa by SDS-PAGE under non-reducing conditions. *Human LIGHT(Catalog Number 310-09B) has replaced Human LIGHT(Catalog Number 310-09)

DETAILS

  • Gene Id: 8740
  • Uniprot: O43557
  • Activity: Determined by its ability to induce IL-8 secretion in human BEAS-2B cells.
  • Category: RUO Cytokines
  • Subcategory: Growth Factors & Cytokines
  • Research Areas: Apoptosis, Cancer, Immune System, Inflammation
  • Alternative Names: TNFSF14, HVEM-L
  • Species of Origin: Human
  • Expression System Source: Hi-5 Insect cells