Polyclonal Antibody to GSK3 Alpha/beta(Phospho-Tyr279/216)

DESCRIPTION

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Chin PC, et al. Brain Res Mol Brain Res 2005 Jun 13; 137(1-2): 193-201 Takahashi-Yanaga F, et al. Biochem Biophys Res Commun 2004 Apr 02; 316(2): 411-415 Fan G, et al. J Biol Chem 2003 Dec 26; 278(52): 52432-52436 iao X, et al. Mol Cancer Ther 2003 Nov; 2(11): 1215-1222

DETAILS

Gene: GSK3A
App Id: IHC,WB,IF
Antigen: GSK3 Alpha/ Beta(Phospho-Tyr279/216)
Gene Id: 2931
Isotype: Rabbit IgG
Format Id: Purified
Uniprot Id: P49840/P49841
Host Animal: Rabbit
Clonality Id: Polyclonal
Reactivity Id: Rat,Mouse,Human
Product Content: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Alternative Name: Factor A|| GSK-3 alpha/beta|| kinase GSK3-alpha/beta
Application Note: Predicted MW: 46, 51kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Storage Condition: Store the antibody at 4°C, stable for 6 months. For ong-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: Peptide sequence around phosphorylation site of tyrosine 279/216 (V-S-Y(p)-I-C) derived from Human GSK3 alpha/beta.