mouse monoclonal IgG1; Musclin Antibody (D-7) is an IgG1 κ mouse monoclonal Musclin antibody (also designated Musclin antibody) that detects the Musclin protein of human origin by WB, IP, IF and ELISA. Musclin Antibody (D-7) is available as both the non-conjugated anti-Musclin antibody form, as well as multiple conjugated forms of anti-Musclin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Musclin, also designated osteocrin (Ostn), shows no homology with any known genes, except that it contains two conserved sequence motifs homologous to the natriuretic peptide family. Musclin is highly expressed in cells of osteoblast lineage and in skeletal muscle tissue, where it is tightly regulated by nutritional changes. It is secreted as either a full-length precursor protein or a processed form. A novel skeletal muscle-derived secretory factor, Musclin may play a role in bone formation and be linked to glucose metabolism. Studies indicate that insulin increases Musclin expression, whereas epinephrine, isoproterenol and forskolin reduce its expression. Musclin is expressed in osteoblasts and young osteocytes. In mouse tissues, expression is bone-specific, although minimal Musclin expression is also observed in muscle, kidney, testis and heart tissues.