Reglitazar is a PPARɑ agonist and PPARγ agonist. Reglitazar rapidly stimulates glucose disposal rates by enhancing insulin signal transduction in skeletal muscle. Reglitazar improves insulin resistance in genetic and non-genetic insulin-resistant models. Reglitazar reverses hypertriglyceridemia in Zucker fatty and ventromedial hypothalamus-lesioned obese rats.