SPN-C522c-200ug SPN-C522c-1mg SPN-C522c-10mg SPN-C522c-100mg
SARS-CoV-2 Spike Trimer Protein, His Tag (BA.3/Omicron) (MALS verified)
ACROBiosystems
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DESCRIPTION
It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
DETAILS
- Tag: C-10×His
- Host: HEK293
- Size: 100mg
- Buffer: PBS
- Format: Liquid
- Purity: 95%
- Source: SARS-CoV-2 Spike Trimer, His Tag (BA.3/Omicron) (SPN-C522c) is expressed from human 293 cells (HEK293). The spike mutations are identified on the SARS-CoV-2 Omicron variant (Pango lineage: BA.3; GISAID clade: GRA; Nextstrain clade: 21M). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.
- Storage: -70℃
- Category: Viral Proteins
- Molecule: Spike protein
- Accession: QHD43416.1 (A67V,H69del,V70del,T95I,G142D,V143del,Y144del,Y145del,N211del,L212I,G339D,S371F,S373P,S375F,D405N,K417N,N440K,G446S,S477N,T478K,E484A,Q493R,Q498R,N501Y,Y505H,D614G,H655Y, N679K,P681H,N764K,D796Y,Q954H,N969K,R683A, R685A, F817P, A892P, A899P, A
- Conjugate: Unconjugated
- Stability: ● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 3 months under sterile conditions.
- Package Size: 100mg*1
- Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 137.8 kDa. The protein migrates as 160-200 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level: 1.0 EU per μg
- Molecular Weight: 137.8 kDa
- Shipping Condition: Dry ice
- Species Reactivity: SARS-CoV-2
- Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html