mouse monoclonal IgG2a; XPF Antibody (F-11) is an IgG2a κ mouse monoclonal XPF antibody (also designated XPF protein antibody, XPF antibody antibody, ERCC Excision Repair 4 antibody, Endonuclease Catalytic Subunit antibody, DNA Repair Protein Complementing XP-F Cells antibody, DNA Excision Repair Protein ERCC-4 antibody, DNA Repair Endonuclease XPF antibody, ERCC11 antibody, or FANCQ antibody) that detects the XPF protein of mouse, rat and human origin by WB, IP, IF and ELISA. XPF Antibody (F-11) is available as both the non-conjugated anti-XPF antibody form, as well as multiple conjugated forms of anti-XPF antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by a genetic predisposition to sunlight-induced skin cancer, and it is commonly due to deficiencies in DNA repair enzymes. The most frequent mutations are found in the XP genes from group A through G and group V, which encode for nucleotide excision repair proteins. XPF, which is also designated ERCC4 or ERCC11, is a protein that associates directly with the excision repair cross-complementing 1 (ERCC1) factor. ERCC-1, a functional homolog of Rad10 in S. cerevisiae, is a component of a structure-specific endonuclease that is responsible for 5′ incisions during DNA repair. The ERCC1-XPF endonuclease preferentially cleaves one strand of DNA between duplex and single-stranded regions near borders of the stem-loop structure and, thereby, contributes to the initial steps of the nucleotide excision repair process.