1489782-25mg 1489782-10mg
SCR7 pyrazine
Biogems
DESCRIPTION
SCR7 pyrazine is a DNA ligase IV inhibitor which blocks nonhomologous end-joining (NHEJ). It is reported to increase the efficiency of homology-directed repair (HDR) up to 19 fold. SCR7 pyrazine is also reported to inhibit cancer cell growth and enhances the cytotoxic effects of radiation in in vivo mouse models.
DETAILS
- Purity: ≥95%
- Synonyms: 2-mercapto-6,7-diphenylpteridin-4-ol, 6,7-diphenyl-2-sulfanyl-3H-pteridin-4-one
- Cas Number: 14892-97-8
- References: Maruyama, T., Dougan, S. K., Truttmann, M. C., Bilate, A. M., Ingram, J. R., & Ploegh, H. L. (2015). Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. Nature biotechnology, 33(5), 538-542. Vartak, S. V., & Raghavan, S. C. (2015). Inhibition of nonhomologous end joining to increase the specificity of CRISPR/Cas9 genome editing. FEBS journal, 282(22), 4289-4294. Srivastava, M., Nambiar, M., Sharma, S., Karki, S. S., Goldsmith, G., Hegde, M., ... & Natarajan, R. (2012). An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression. Cell, 151(7), 1474-1487.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one
- Molecular Weight: 332.4
- Molecular Formula: C18H12N4OS
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: C1=CC=C(C=C1)C2=NC3=C(NC(=S)NC3=O)N=C2C4=CC=CC=C4