830-GG2
Promo Available
Anti-GABAA Receptor γ2 Antibody
PhosphoSolutions
DESCRIPTION
Our Anti-GABAA Receptor γ2 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects mouse and rat GABAA Receptor γ2 and is neat pooled serum. It is great for use in WB, IHC.
DETAILS
- Form: Neat Pooled Serum
- Gene: GABRG2
- Host: Rabbit
- Rrid: AB_2492114
- Type: Primary Antibody
- Buffer: neat serum
- Target: GABAA Receptor γ2
- Isotype: IgG
- Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
- Shipping: Blue Ice
- Synonyms: CAE 2 antibody, CAE2 antibody, ECA 2 antibody, ECA2 antibody, GABA(A) receptor gamma 2 antibody, GABA(A) receptor subunit gamma 2 antibody, GABA(A) receptor subunit gamma-2 antibody, GABRG 2 antibody, GABRγ2 antibody, Gamma aminobutyric acid (GABA) A receptor gamma 2 antibody, Gamma aminobutyric acid A receptor gamma 2 antibody, Gamma aminobutyric acid receptor gamma 2 subunit antibody, Gamma-aminobutyric acid receptor subunit gamma-2 antibody, GBRG2_HUMAN antibody, GEFSP 3 antibody, GEFSP3 antibody
- Clonality: Polyclonal
- Immunogen: Synthetic peptide corresponding to amino acid residues specific to the γ2 subunit of rat GABAA receptor, conjugated to keyhole limpet hemocyanin (KLH).
- Expiration: After date of receipt, stable for at least 1 year at -20°C.
- Specificity: Specific for endogenous levels of the ~46 kDa γ2-subunit of the GABAA receptor.
- Applications: WB, IHC
- Ncbi Gene Id: 29709
- Conjugate Exem: Unconjugated
- Physical State: Liquid
- Quality Control: Western blots performed on each lot.
- Usage Statement: For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
- Molecular Weight: 46
- Production Notes: Pooled neat serum
- Dilution Range Wb: 1:1000
- Immunogen Species: Rat
- Dilution Range Ihc: 1:400
- Species Reactivity: Mouse and Rat
- Target Description: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABA-A receptor (GABA-A-R) subtype. GABA-A-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABA-A-Rs sensitive to GABA. However, co-expression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α- subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003). Lastly, phosphorylation of β-subunits of the receptor has been shown to modulate GABA-A-R function (Brandon et al., 2003).
- Expected Reactivity: Chicken, Human, Non-Human Primate, Zebrafish
- Dilution Range Wb Brain: 1:1000
- Uniprot Number Immunogen Species: P18508
PROMOTION TERMS
Trial Size Available. Limit 1
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