Anti-JNK1 (C-terminal region) Antibody

DETAILS

Form: Protein A Purified
Gene: MAPK8
Host: Mouse
Rrid: AB_2140696
Type: Primary Antibody
Clone: M267
Buffer: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Target: JNK1 (C-terminal region)
Isotype: IgG1
Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Shipping: Blue Ice
Synonyms: SAPK1, p49MAPK, MAPK. Mitogen-activated protein kinase 8, c-Jun N-terminal kinase 1, Stress-activated protein kinase JNK1, Stress-activated protein kinase 1c (SAPK1c), JNK-46
Clonality: Mouse Monoclonal
Immunogen: Clone M267 was generated from a recombinant protein corresponding to amino acid residues in the C-terminal region of human JNK1. This sequence has high homology to rat and mouse JNK1, and has homology to similar regions in JNK2 and JNK3.
Expiration: After date of receipt, stable for at least 1 year at -20°C.
Specificity: This antibody detects a 46 kDa* protein corresponding to the apparent molecular mass of JNK1 on SDS-PAGE immunoblots of human A431 and HeLa, as well as rat PC12 cells.
Applications: WB, ICC, IHC
Conjugate Exem: Unconjugated
Physical State: Liquid
Quality Control: Western blots performed on each lot.
Usage Statement: For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
Molecular Weight: 46
Dilution Range Wb: 1:1000
Immunogen Species: Human
Dilution Range Icc: 1:100
Dilution Range Ihc: 1:100
Species Reactivity: Human, Mouse, and Rat
Target Description: The stress-activated protein kinases (SAPK) or Jun-amino-terminal kinases (JNK) are potently activated by stressors such as UV and gamma radiation. Similar to other MAP Kinases, the core signaling unit is composed of a MAPKKK, usually MEKK1-4 or a mixed lineage kinase (MLK), which phosphorylate and activate MKK4-7, leading to dual phosphorylation and activation of JNK kinases. Rho-GTPases (Rac1 and cdc42) can stimulate MEKKs and MLKs, while MKKs can be activated by a GTPase-independent pathway that involves the germinal center kinase family. There are three JNK genes (JNK1, 2, 3) with further diversification resulting from alternative splicing. Active JNK dimers can translocate to the nucleus to regulate transcription through phosphorylation of c-Jun, ATF-2 and other transcription factors.
Uniprot Number Immunogen Species: P45983
Post Translational Modification Type: GOmAb