• Aa: 1-1152 (end)
• Mw: 156 kDa
• Tags: N-Terminal GST Tag
• Format: Aqueous buffer solution.
• Purity: ≥80%
• Genbank: XM_003752010.4
• Species: Rat
• Uniprot: A0A0G2QC41
• Shiptemp: -80°C (dry ice)
• Synonyms: LOC103689963, LOC108348065, Hdac6, Histone deacetylase 6
• Warnings: Avoid freeze/thaw cycles
• Category: Deacetylases/Protein
• Background: Histone Deacetylases (HDACs) are involved in histone deacetylation, which regulates transcription. HDAC6 is involved in multiple cellular processes, such as leptin sensitivity, cell motility, mitosis and stress granule formation. Overexpression of HDAC6 is linked to tumor formation, and mutations have been associated with Alzheimer's disease.  The use of HADC6 inhibitors presents high therapeutic potential for the treatment of neurodegenerative diseases and cancer.
• Constructs: HDAC6(GST-1-1152(end))
• Description: Recombinant rat full length HDAC6 (Histone Deacetylase 6) encompassing amino acids 1-1152(end). The construct contains a N- terminal GST-Tag. This protein was affinity purified
• Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20 and 20% glycerol
• Unspsc Code: 12352202
• Unspsc Name: Proteins
• Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Host Species: insect
• Product Type: Protein
• Host Cell Line: Sf9 cells
• Biosafety Level: Not applicable (BSL-1)
• Assay Conditions: Assay was done according to HDAC6 Fluorogenic Assay Kit (BPS Bioscience #50076) with various amounts of HDAC6.
• Related Products: 50076, 50056, 50046
• Specific Activity: ≥530 pmol/min/µg
• Storage Stability: At least 6 months at -80°C.
• Scientific Category: Deacetylases
• Instructions for Use: Thaw on ice and gently mix prior to use. DO NOT VORTEX. Perform a quick spin before opening. Aliquot into small volumes and flash freeze for long term storage. Avoid multiple freeze/thaw cycles.

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