15(S)-HETE

DESCRIPTION

An active metabolite of arachidonic acid; inhibits proliferation of HT-29 colorectal and PC3 prostate cancer cells (IC50s = 40 and 30 µM, respectively); increases KLF10 and decreases Bcl-2 protein levels in HT-29 cells at 40 µM; increases HMG-CoA reductase levels in HDMVECs at 0.1 µM; increases Rac1 protein levels and induces farnesylation of Rac1 in HDMVECs at 0.1 µM

DETAILS

Inchi: InChI=1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+/t19-/m0/s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Lipids|Hydroxy/Hydroperoxy/Epoxy/Oxo Eicosanoids||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|GTPases||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Fatty Acids||Research Area|Lipid Biochemistry|Lipoxygenase Pathways
Smiles: CCCCC[C@H](O)/C=C/C=C\C/C=C\C/C=C\CCCC(O)=O
Inchikey: JSFATNQSLKRBCI-VAEKSGALSA-N
Cas Number: 54845-95-3
Formulation: A solution in ethanol
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C20H32O3
Formula Weight: 320.5
Shelf Life Days: 365