Forskolin

DESCRIPTION

Forskolin activates the enzyme adenylyl cyclase and increases intracellular levels of cyclic AMP (cAMP). It has vasodilator and hypotensive properties and can be used to induce neuronal differentiation in stem cells. In combination with other small molecules, it is also reported to be utilized in the chemical reprogramming of embryonic fibroblasts to induced pluripotent stem cells.

DETAILS

Purity: ≥98%
Synonyms: Coleonol, colforsin, NKH-477, NSC 375489
Cas Number: 66575-29-9
References: Seamon, K. B., & Daly, J. W. (1980). Forskolin: a unique diterpene activator of cyclic AMP-generating systems. Journal of cyclic nucleotide research, 7(4), 201-224. Laurenza, A., Sutkowski, E. M., & Seamon, K. B. (1989). Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?.Trends in Pharmacological Sciences, 10(11), 442-447. Shamblott, M. J., Axelman, J., Wang, S., Bugg, E. M., Littlefield, J. W., Donovan, P. J., ... & Gearhart, J. D. (1998). Derivation of pluripotent stem cells from cultured human primordial germ cells. Proceedings of the National Academy of Sciences, 95(23), 13726-13731.
Application: FA
Formulation: Crystalline solid
Chemical Name: [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate
Molecular Weight: 410.5
Molecular Formula: C22H34O7
Storage Conditions: Product should be kept at -20°C.
Pubchem Openeye Can Smiles: CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)O