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Recombinant Human GM-CSF



GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages, and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant Human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids, containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites.


  • Gene Id: 1437
  • Uniprot: P04141
  • Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg.
  • Category: RUO Cytokines
  • Subcategory: Growth Factors & Cytokines
  • Research Areas: Cancer, Cell Culture, Immune System, Inflammation, Stem Cells and Differentiation, Wound Healing, COVID-19
  • Alternative Names: Granulocyte-Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, Pluripoietin-alpha
  • Species of Origin: Human
  • Expression System Source: E.coli