sc-166940 SAMPLE sc-166940
Promo Available
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c-Fos (E-8)
Santa Cruz Biotechnology
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DESCRIPTION
mouse monoclonal IgG1; c-Fos Antibody (E-8) is an IgG1 κ mouse monoclonal c-Fos antibody that detects the c-Fos protein of m, r, h, zebrafish origin by WB, IP, IF, IHC(P) and ELISA. c-Fos Antibody (E-8) is available as both the non-conjugated anti-c-Fos antibody form, as well as multiple conjugated forms of anti-c-Fos antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The c-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phospho-protein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. Functional homologs of c-Fos include the Fra-1, Fra-2 and Fos B genes. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.
DETAILS
- Host: mouse
- Type: Primary
- Uniprot: P15408
- Clonality: Monoclonal
- Conjugate: unconjugated
- Applications: WB, IP, IF, IHC(P), ELISA
- Human Gene Id: 2353 2354 8061 2355
- Mouse Gene Id: 14281 14282 14283 14284
- Protein Target: c-Fos, Fos B, Fra-1 and Fra-2
- Human Gene Name: FOS, FOSB, FOSL1, FOSL2
- Mouse Gene Name: Fos, Fosb, Fosl1, Fosl2
- Species Reactivity: mouse, rat, human, zebrafish
PROMOTION TERMS
Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.