RP00060
Recombinant Human TNFSF9/4-1BB Ligand Protein
ABclonal
DESCRIPTION
The protein is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
DETAILS
- Tag: C-His
- Source: E. coli
- Gene Id: 8744
- Species: Human
- Lead Time: 3-5 weekdays
- Swiss Prot: P41273
- Research Areas: Immune Checkpoint,TNF family
- Alternative Names: 4-1BB-L, CD137L, TNLG5A,TNFSF9,CD137L,TNLG5A
Equivalent Items
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