5911439-1g 5911439-250mg
BrdU
Biogems
DESCRIPTION
BrdU is a synthetic nucleoside that is an analog of thymidine and is commonly used in the detection of proliferating cells in living tissues. It is reported that BrdU can be used to promote chemical induction of mouse iPSCSs in conjunction with other chemical reagents including, CHIR 99021, ALK5 Inhibitor (RepSox), and Forskolin. BrdU is also reported to induce a sustained reduction in the proliferation rate of cancer cells.
DETAILS
- Purity: ≥98%
- Synonyms: Bromodeoxyuridine, Broxuridine, 5-Bromo-2'-deoxyuridine, 5-BrdU, 5-Bromouracil deoxyriboside, 5-Bromo-2-deoxyuridine
- Cas Number: 59-14-3
- References: Taupin, P. (2007). BrdU immunohistochemistry for studying adult neurogenesis: paradigms, pitfalls, limitations, and validation. Brain research reviews, 53(1), 198-214. Long, Y., Wang, M., Gu, H., & Xie, X. (2015). Bromodeoxyuridine promotes full-chemical induction of mouse pluripotent stem cells. Cell research. Levkoff, L. H., Marshall, G. P., Ross, H. H., Caldeira, M., Reynolds, B. A., Cakiroglu, M., ... & Laywell, E. D. (2008). Bromodeoxyuridine inhibits cancer cell proliferation in vitro and in vivo. Neoplasia, 10(8), 804-IN13.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 5-bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
- Molecular Weight: 307.1
- Molecular Formula: C9H11BrN2O5
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: C1C(C(OC1N2C=C(C(=O)NC2=O)Br)CO)O