mouse monoclonal IgG2a; connexin 30 Antibody (G-2) is an IgG2a κ mouse monoclonal connexin 30 antibody (also designated GJB6 antibody, gap junction protein beta 6 antibody, or CX30 antibody) that detects the connexin 30 protein of mouse, rat and human origin by WB, IP, IF and ELISA. connexin 30 Antibody (G-2) is available as both the non-conjugated anti-connexin 30 antibody form, as well as multiple conjugated forms of anti-connexin 30 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The connexin family of proteins form hexameric complexes called connexons that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane alpha-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences between connexins arise from specific amino-acid substitutions in the most highly conserved domains: the transmembrane and extracellular regions. Connexin 30, also known as GJB6 (Gap junction beta 6), ED2, EDH, HED or DFNA3, is a 261 amino acid multi-pass membrane protein that localizes to the cell junction and belongs to the connexin family. Functioning as a hexamer with other connexin proteins, connexin 30 facilitates the diffusion of low molecular weight materials from one cell to another. Defects in the gene encoding connexin 30 are the cause of ectodermal dysplasia type 2 (ED2) and non-syndromatic sensorineural deafness autosomal dominant type 3 (DFNA3), the former of which is characterized by abnormal development of ectodermal structures (such as skin and nails).