Bryostatin 1

DESCRIPTION

A marine macrolide with diverse biological activities; binds to PKCα, PKCβ1, PKCγ, PKCδ, PKCε, PKCη, and PKCθ (Kis = 0.8-3.0 nM); induces PKC activation or inhibition in cancer cells in a concentration-dependent manner; reduces the production of IL-2 and increases the production of IL-10 in LPS-stimulated mouse BMDCs at 50 nM; decreases cell surface levels of CD4 and CCR5 and reduces HIV-1 infectivity in isolated human monocyte-derived macrophages; reduces spinal cord and brain T cell infiltration and disease severity in a mouse model of EAE at 30 µg/kg; decreases blast-induced increases in BBB permeability in a rat model of TBI at 2.5 mg/kg

DETAILS

Inchi: InChI=1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Activators|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PKC Signaling||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Neuroscience|Neurodegenerative Disorders|Multiple Sclerosis||Research Area|Neuroscience|Neuroprotection
Smiles: O[C@](O[C@@](C[C@](OC(C[C@@H](C[C@@](C1)([H])O2)O)=O)([H])[C@H](O)C)([H])C/C3=C\C(OC)=O)(C(C)(/C=C/[C@](C/C4=C\C(OC)=O)([H])O[C@](C4)([H])C[C@]2(C(C)([C@H]1OC(C)=O)C)O)C)[C@H]3OC(/C=C/C=C/CCC)=O
Inchikey: MJQUEDHRCUIRLF-TVIXENOKSA-N
Cas Number: 83314-01-6
Formulation: A lyophilized powder
Item Origin: Animal/Bugula neritina
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C47H68O17
Formula Weight: 905
Shelf Life Days: 1460