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4744-MSM3-P0 4744-MSM3-P1 4744-MSM3-P1ABX

Neurofilament, phospho (NF-H) (Neuronal Marker) - CloneID - NE14

NeoBiotechnologies

DESCRIPTION

This MAb reacts with a 200kDa protein, identified as heavy sub-unit of neurofilaments (NF-H). It reacts specifically with the phosphorylated KSP/KEP segment at the C-terminus of the heavy subunit (NF-H) of neurofilaments. After dephosphorylation of neurofilaments with alkaline phosphatase, this Ab no longer binds. Neurofilaments make up the main structural elements of axons and dendrites and are found in neurons, peripheral nerves, and sympathetic ganglion cells. Neurofilaments consist of three major subunits with molecular weights of 68kDa (NF-L), 160kDa (NF-M) and 200kDa (NF-H). Anti-neurofilament stains a number of neural, neuroendocrine, and endocrine tumors. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, and neuroblastomas stain positively for anti-neurofilament. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilament.

DETAILS

  • Host: Mouse
  • Gene ID: 4744
  • Uniprot: P12036
  • Clone ID: NE14
  • Clonality: Monoclonal
  • Gene Name: NEFH
  • Supplied As: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
  • Applications: FLOW, IHC, WB
  • Protein Target: NEFH
  • Species Reactivity: Human, Mouse, Rat, Guinea Pig, Gerbil, Cat, Pig, Rabbit, Cow, Chicken
  • Storage Conditions: Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80 C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.