55107-MSM2-P0 55107-MSM2-P1 55107-MSM2-P1ABX
DOG-1 / TMEM16A (Marker for Gastrointestinal Stromal Tumors) - CloneID - DOG-1.1
NeoBiotechnologies
DESCRIPTION
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4% vs. 94.7%.
DETAILS
- Host: Mouse
- Gene ID: 55107
- Uniprot: Q5XXA6
- Clone ID: DOG-1.1
- Clonality: Monoclonal
- Gene Name: TMEM16A
- Supplied As: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
- Protein Target: TMEM16A
- Species Reactivity: Human, Others not known
- Storage Conditions: Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80 C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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