30-2786
Anti-Hu CD367 Purified
Abeomics
DESCRIPTION
CD367 is an approximately 20-28 kDa C-type lectin with immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic part. CD367 binds in calcium-dependent manner to mannose, fucose, and weakly also to N-acetylglucosamine. It is expressed on dendritic cells, macrophages, monocytes, B cells, and neutrophils. In rheumatoid arthitis patients CD367 is expressed also on CD4+ T cells. After ligand-mediated triggering, it is internalized by clathrin-dependent endocytosis and contributes to the antigen presentation to CD8+ T cells. It may also be involved in modulation of the antigen presenting cell response.Specificity :The mouse monoclonal antibody 9E8 recognizes an extracellular epitope of human CD367, a type II transmembrane protein of C-lectin family, expressed mainly on antigen presenting cells.
DETAILS
- Gene: CLEC4A
- App Id: ICC, FACS, ELISA
- Antigen: CD367
- Gene Id: 50856
- Format Id: Purified
- Clone Name: Clone: 9E8
- Uniprot Id: Q9UMR7
- Clonality Id: Monoclonal
- Purification: Purified by protein-A affinity chromatography.
- Reactivity Id: Non-human primates, Human
- Product Content: Storage Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Alternative Name: C-type lectin domain family 4 member A DCIR, CLEC4A, LLIR
- Application Note: Flow cytometry: Recommended dilution: 1-4 µg/ml
- Storage Condition: Store at 2-8°C. Do not freeze.
- Immunogen Information: CD367 ectodomain fused with human Fc