DESCRIPTION

• Aa: 25-167
• Mw: 44.5 kDa+glycans
• Tags: C-terminal AviTag™
• Notes: The aggregation state of this product has been confirmed to be <10%.
• Format: Aqueous buffer solution
• Genbank: NM_014143
• Species: Human
• Uniprot: Q15116
• Shiptemp: -80°C (dry ice)
• Synonyms: Programmed cell death 1, PDCD1, PD-1, PD1, SLEB2, CD279, HPD-L
• Warnings: Avoid freeze/thaw cycles. Protein may be diluted to ≥100 µg/ml in PBS + glycerol and stored at -80°C.
• Category: Immunotherapy/Protein
• References: 1. Freeman, G.J., et al., J. Exp. Med. 2000 Oct 2;192(7):1027-34. 2. Dong, H., et al., Nat Med. 1999. Dec;5(12):1365-9.
• Description: Human secreted Programmed Cell Death 1 (PD-1)-Fc fusion protein, also known as CD279, PDCD1, and SLEB2, GenBank Accession No. NM_014143, a.a. 25-167 with an I134A mutation, fused at the Cterminus with the Fc portion of human IgG1, and C-terminal AviTag™, expressed in a HEK293 cell expression system and enzymatically biotin-labeled using AviTag™ technology. MW = 44.5 kDa. This protein runs at a higher MW by SDS-PAGE due to glycosylation.
• Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, pH 7.4, and 20% glycerol
• Unspsc Code: 12352202
• Unspsc Name: Proteins
• Applications: Useful for the study of protein-protein interaction and in vitro and in vivo protein function.
• Product Type: Protein
• Biosafety Level: Not applicable (BSL-1)
• Related Products: 71238, 71244, 71246, 71247, 71248, 79512, 79670
• Storage Stability: At least 6 months at -80°C.
• Scientific Category: Immunotherapy