Rosuvastatin . calcium salt

DESCRIPTION

Rosuvastatin is a potent competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the statin class of cholesterol-lowering drugs. Rosuvastatin is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. Formulations containing rosuvastatin reduce low-density lipoprotein (LDL) and C-reactive protein and increase high-density lipoprotein (HDL) in humans. Shown to have anti-inflammatory, antioxidant, antithrombotic and insulin sensitizing properties. Identified as a potential inhibitor of SARS-CoV-2, responsible for COVID-19.

DETAILS

Cas: 147098-20-2
Rtecs: MJ9675070
Purity: greater than or equal to 98% (HPLC)
Smiles: CN(S(C)(=O)=O)C1=NC(C2=CC=C(F)C=C2)=C(/C=C/[C@H](C[C@@H](O)CC([O-])=O)O)C(C(C)C)=N1.[Ca+2]
Formula: C22H27FN3O6S . 1/2Ca
Storage: Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
Identity: Determined by 1H-NMR.
Shipping: Room Temp
Inchi Key: VGAZDTHGPVFCCO-YFRSHGDPSA-K
Solubility: Soluble in DMSO or ethanol. Insoluble in water.
Physical State: Lyophilized
Additional Names: Crestor
Predicted Molecular Weight: 480.6 . 20.0