30-2755
Anti-Hu CD79b PE
Abeomics
DESCRIPTION
CD79b (Ig beta, B29) forms disulfide-linked heterodimer with CD79a (Ig alpha, MB1). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.Specificity :The mouse monoclonal antibody CB3-1 recognizes an extracellular epitope of CD79b (CD79 beta, Ig beta), an approximately 38 kDa component of B cell receptor (BCR) complex.
DETAILS
- Gene: CD79B
- App Id: FACS
- Antigen: CD79b
- Gene Id: 974
- Clone Name: CB3-1
- Uniprot Id: P40259
- Clonality Id: Monoclonal
- Conjugate Id: PE
- Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reactivity Id: Human
- Product Content: Concentration: 1 mg/mlStorage Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Alternative Name: CD79b molecule BCR beta, Ig-beta, B29, IGB
- Application Note: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 µl reagent / 100 µl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
- Storage Condition: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
- Immunogen Information: Fraction of Ig-associated molecules isolated from Ramos B cells
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