Vatiquinone

DESCRIPTION

A metabolite of α-tocotrienol that has antioxidant and ferroptosis inhibitory activity; inhibits BSO-induced decreases in cell in primary fibroblasts isolated from patients with Friedreich's ataxia or Leigh syndrome (EC50s = 24 and 30 nM, respectively); inhibits RSL3-induced cell death and lipid peroxidation in primary fibroblasts isolated from patients with PCH6 (EC50s = 17.3-21.8 and 33.1-57.6 nM, respectively)

DETAILS

Inchi: InChI=1S/C29H44O3/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8,32)19-17-26-25(7)27(30)23(5)24(6)28(26)31/h12,14,16,32H,9-11,13,15,17-19H2,1-8H3/b21-14+,22-16+/t29-/m1/s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Antioxidants||Product Type|Biochemicals|Natural Products|Vitamins||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Neuroscience|Neuroprotection|Ischemia||Research Area|Neuroscience|Seizure Disorders||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Nitrogen||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione||Research Area|Toxicology & Xenobiotic Metabolism|Drug Metabolites
Smiles: O=C1C(C)=C(C)C(C(CC[C@@](O)(C)CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)=C1C)=O
Inchikey: LNOVHERIIMJMDG-XZXLULOTSA-N
Cas Number: 1213269-98-7
Formulation: A solution in ethanol
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C29H44O3
Formula Weight: 440.7
Shelf Life Days: 365