1664317-25mg 1664317-10mg
BMS 453
Biogems
DESCRIPTION
BMS 453 is a synthetic retinoid and RARα and RARγ antagonist and a RARβ agonist. It is reported to induce TGF-Beta activity and cause G1 arrest and inhibit breast cell proliferation. BMS 453 also increases the efficiency of human ESCs cardiac differentiation.
DETAILS
- Purity: ≥98%
- Synonyms: BMS453, BMS-453, BMS-189453
- Cas Number: 166977-43-1
- References: Chen, J. Y., Clifford, J., Zusi, C., Starrett, J., Tortolani, D., Ostrowski, J., ... & Gronemeyer, H. (1996). Two distinct actions of retinoid-receptor ligands. Nature, 382(6594), 819. Zhang, Q., Jiang, J., Han, P., Yuan, Q., Zhang, J., Zhang, X., ... & Tian, T. (2011). Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals. Cell research, 21(4), 579. Barnard, J. H., Collings, J. C., Whiting, A., Przyborski, S. A., & Marder, T. B. (2009). Synthetic retinoids: structure–activity relationships. Chemistry-A European Journal, 15(43), 11430-11442.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 4-[(E)-2-(5,5-dimethyl-8-phenyl-6H-naphthalen-2-yl)ethenyl]benzoic acid
- Molecular Weight: 380.5
- Molecular Formula: C27H24O2
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CC1(CC=C(C2=C1C=CC(=C2)C=CC3=CC=C(C=C3)C(=O)O)C4=CC=CC=C4)C
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