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GFA-M52H7-100ug GFA-M52H7-1mg

Mouse GFR alpha-like Protein, His Tag

ACROBiosystems

DESCRIPTION

Mouse GFR alpha-like, His Tag (GFA-M52H7) is expressed from human 293 cells (HEK293). It contains AA Gln 20 - Gly 349 (Accession # Q6SJE0-1).

DETAILS

  • Tag: C-10×His
  • Host: HEK293
  • Size: 100ug
  • Buffer: PBS, pH7.4
  • Format: Powder
  • Purity: 95%
  • Storage: -20℃
  • Category: Other Recombinant Proteins
  • Molecule: GFR alpha-like
  • Accession: NP_995316.2
  • Conjugate: Unconjugated
  • Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
  • Background: GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
  • Exp Region: Gln 20 - Gly 349
  • Swiss-prot: Q6SJE0-1
  • Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 39.0 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Endotoxin Level: 1.0 EU per μg
  • Molecular Weight: 39.0 kDa
  • Shipping Condition: RT
  • Species Reactivity: Mouse
  • Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html