AMG-548 hydrochloride (864249-60-5 free base)

DESCRIPTION

AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50: 3 nM).

DETAILS

Cas: T10298
Purity: 98%
Smiles: O=C1N(C)C(NCC(N)CC2=CC=CC=C2)=NC(C3=CC=NC=C3)=C1C4=CC=C5C=CC=CC5=C4.Cl
Category: Compound
Molecular Weight: 498.02
Molecular Formula: C29H28ClN5O

Lead Time: 4 - 5 weeks