Rabbit Growth Hormone R (GHR) Protein, His Tag

DESCRIPTION

Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

DETAILS

Tag: C-10×His
Host: HEK293
Size: 1mg
Buffer: PBS, pH7.4
Format: Powder
Purity: 90%
Source: Rabbit Growth Hormone R, His Tag (GHR-R52H9) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Arg 264 (Accession # P19941-1).
Storage: -20℃
Category: Bio-Markers & CD Antigens
Molecule: Growth Hormone R
Accession: NP_001076105.1
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Ala 27 - Arg 264
Swiss-prot: P19941-1
Package Size: 1mg*1
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 29.3 kDa. The protein migrates as 36-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 29.3 kDa
Shipping Condition: RT
Species Reactivity: Rabbit
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